Absence of measurable leukocyte alkaline phosphatase activity from leukocytes of patients with chronic granulocytic leukemia.
نویسندگان
چکیده
I. Broughton, P.M.G., A rapid ultraviolet spectrophometric method for detection, estimation and identification of barbiturates in biological material. Biochein. J. 63, 207 (1956). 2. Stevenson, W. G., Spectrophotometric determination of blood barbiturate. Anal. Chm. 33, 1374 (1961). 3. Bjorling, C. 0., Berggren, A., and Willman-Johnson, B., I)etermination of barbituric acid derivatives as mercury complexes. J. Pharm. Pharmacol. 11, 297 (1959).
منابع مشابه
Bullous eruption and elevated leukocyte alkaline phosphatase in the course of busulfan-treated chronic granulocytic leukemia.
IHRONIC GRANULOCYTIC LEUKEMIA is characterized by hepatosplenomegaly, a markedly elevated white blood cell count with a spectrum of immature and mature granulocytic elements present, a proliferative granulocytic bone marrow, low levels or absence of leukocyte alkaline phosphatase activity and the presence of the Philadelphia chromosome.’ The patient to be described had chronic granulocytic leuk...
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The alkaline phosphatase of leukocytes from normal subjects, patients with chronic granulocytic leukemia, and patients with reactive granulocytosis have been characterized by means of agarose column chromatography, sucrose density ultracentrifugation, starch gel electrophoresis, Michaelis constant for p-nitrophenyl phosphate, heat inactivation, inhibition by L-phenylalanine, Ouchterlony double ...
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The alkaline phosphatase of leukocytes from normal subjects, patients with chronic granulocytic leukemia, and patients with reactive granulocytosis have been characterized by means of agarose column chromatography, sucrose density ultracentrifugation, starch gel electrophoresis, Michaelis constant for p-nitrophenyl phosphate, heat inactivation, inhibition by L-phenylalanine, Ouchterlony double ...
متن کاملA comparison of human leukocyte phosphatase activity toward sodium beta-glycerophosphate, adenosine 5'-phosphate and glucose 1-phosphate.
F OR A NUMBER OF YEARS this laboratory has been interested in the phosphatase activity of isolated human leukocytes and the marked lability of leukocyte alkaline phosphatase in disease.1 3 Leukocyte alkaline phosphatase has been demonstrated to be essentially limited to the granulocytic cells and to be characteristically low in chronic myelocytic leukemia. Elevated values are noted in polycythe...
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F OR A NUMBER OF YEARS this laboratory has been interested in the phosphatase activity of isolated human leukocytes and the marked lability of leukocyte alkaline phosphatase in disease.1 3 Leukocyte alkaline phosphatase has been demonstrated to be essentially limited to the granulocytic cells and to be characteristically low in chronic myelocytic leukemia. Elevated values are noted in polycythe...
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ورودعنوان ژورنال:
- Clinical chemistry
دوره 16 9 شماره
صفحات -
تاریخ انتشار 1970